Threshold of Toxicological Concern Dataset (TTC Dataset)

A dataset of 637 chemicals for the Threshold of Toxicological Concern (TTC Dataset) approach has been compiled. This dataset is accessible through this webpage to end-users for scientific research activities and purposes only.

Preparation of the Cancer TTC dataset

The publicly available CPDB database was downloaded from http://potency.berkeley.edu/. The lowest TD50 values from oral studies with significant tumorigenic effects (statistical p-value ≤ 0.01) were selected. The study inclusions also meet the following criteria in accordance with FDA Redbook 2000 recommendations.

  • Positive tumorigenic effects with p ≤ 0.01. TBA (all tumor bearing animals), MXA, and MXB not included
  • Tumors from one cell type (males or females per species)
  • GLP studies or equivalent protocols: appropriate sample size (>40), excluded single dose studies, MTD achieved, and acceptable duration, (18 months mouse, 24 months rats)
  • Shorter exposures are included if results were statistically positive
  • Negative studies with no significant tumor findings excluded
  • Equivocal studies also excluded from this analysis

Features & Functionality

  • 637 structures
  • Connection table information included
  • Chemical name, CAS Registry number, TD50 value, DSSTox generic SID included

Additional Info

Terms of Usage

The data contained and obtained from the TTC dataset ("DATA") may be used by end-users for scientific research activities and purposes only. The DATA in its original or in any transformed format or any derivative work of it whether as a whole or in parts should not be included in or used to build, generate, or create any commercial database and/or software.

Downloadable Files