METIS - Metabolic Information Input System


METIS is designed for the convenient input and storage of information on metabolism and degradation reactions in a database. The resulting database can also be accessed from the CRAFT software suite.

Features & Functionality

  • Graphical input of metabolic pathways and degradation reactions into a database (MySQL) by a convenient and easy-to-use GUI
  • Annotation of the reactions and pathways with additional information
  • Annotation of the reactions and pathways with additional information
  • Input reactions can be used as example reactions in CRAFT applications
  • Open-source application available under EUPL licence version 1.1 only

User Interface

  • GUI-based program to input and store information on metabolism and degradation reactions
  • Includes the graphical reaction editor module MOSES.ReactionEditorEmbedded


  • METIS main application window
    Screenshot of METIS main application window
  • METIS reaction editor - MOSES.ReactionEditorEmbedded module
    Screenshot of METIS reaction editor - MoCo module

System Requirements

  • Microsoft Windows 2000/XP/Vista
  • Instance of MySQL server 5.x (or higher, default storage engine must be InnoDB)
  • Please note: Typically, METIS is used as a supplement to CRAFT software suite, therefore, if CRAFT applications are already installed and configured, the same MySQL database instance will be automatically used by METIS.

Additional Info

Downloadable PDFs

Free Downloads

The downloadable package includes the METIS application, the source code of the parts of METIS that are licensed under the terms of EUPL version 1.1 only as well as the program manual and the installation guide.

METIS employs a graphical reaction editor module (MOSES.ReactionEditorEmbedded) based on MOSES, the proprietary chemoinformatics system of Molecular Networks. The MOSES system, its modules and MOSES.ReactionEditorEmbedded co-distributed with METIS are licensed for the use in conjunction with METIS software only. The detailed license information is included and can be found in the file license.txt in the METIS installation directory.


METIS was developed by Molecular Networks on behalf of the European Commission’s Joint Research Centre, Ispra, Italy.

Copyright Notice

METIS is © 2010 European Union. The program is distributed under the terms of the EUPL licence version 1.1 only.