Visit MN-AM at the 19th National Congress of the Italian Society of Toxicology (SITOX) in Bologna in February 2020

MN-AM.com is attending the upcoming 19th National Congress of the Italian Society of Toxicology, SITOX 2020, in Bologna, Italy, from February 11-12, 2020. We cordially invite you to visit our booth at the exhibition. We will demonstrate our suite of software tools and applications in the area of computational toxicology, safety and risk assessment and read-across. We are available to answer any questions regarding our technology and will be glad to help you finding the right solution for your challenges.
In addition, we will held a pre-congress training course on "Linking In Silico Methods to Navigation of Chemical Safety / Risk Assessment" in the congress hotel (Sala Falco) on Monday, February 10, from 11:00am - 6:30pm. Furthermore, there will be a session and poster presentations related to our technology at the SITOX 2020 Congress.

Please find below a complete list of our contibutions at the SITOX 2020. We are looking forward to meeting you in Bologna.

Pre-Congress Training Course

Linking In Silico Methods to Navigation of Chemical Safety/Risk Assessment
Moderator
  Corrado Lodovico Galli (University of Milan)
Place
  Sala Falco
Time
  Monday, February 10, 2020, 11.30am-6.30pm
Speakers
  Marina Marinovich (University of Milan)
  Elena Fioravanzo (ToxNavigation)
  Mark Cronin (Liverpool John Moores University)
  Chihae Yang (MN-AM)
Topics    All probe molecules
Part 1 - Structure Representation    Part 1 - training material    Part 1 - probe molecule 1    Part 1 - probe molecules 2
Scientific problem statement: structure representation for knowledge and chemical safety
Technical/Chemoinformatics solution
    - How chemical structures are represented and stored by computers (SD and MOL files, SMILES, InChI)
    - Structure-based descriptors: fingerprints (ToxPrints, MACCS keys, RDKIT fingerprints, etc.)
    - How to handle UVCBs
Part 2 - DB Searching & Calculation    Part 2 - training material    Part 2 - probe molecules 1    Part 2 - probe molecule 2
Scientific problem statement: similar structures vs. analogues
Technical/Chemoinformatics solution
    - Calculation of fingerprints, molecular descriptors and physicochemical properties
    - Methods for quantitatively evaluating the similarity between chemical compounds
    - Structure-based similarity, physicochemical property-based similarity, biological similarity
Part 3 - Case Study    Part 3 - training material    Part 3 - probe molecules 4    Part 3 - Read-Across Summary Table
Scientific problem statement: description of cases, both common and difficult
Technical/Chemoinformatics solution
    - (Quantitative) Structure-Activity Relationships: QSAR and Structural rules/alerts
    - Read-Across approach
    - Threshold of Toxicological Concern (TTC)

Session

Leveraging Existing Toxicity Data and Chemoinformatics to Strengthen Chemical Safety Assessment
Moderators
  Ivano Eberini (Milano), Corrado Lodovico Galli (Milano)
Place
  Sala Asinelli
Time
  Tuesday, February 11, 2020, 2-4pm
2.00-2.30pm   Andrew Worth (JRC): Computational modelling for sustainable chemicals management
2.30-3.00pm   Carla Landolfi (ACRAF): In silico toxicity predictions for data-poor chemicals. Applications in the pharmaceutical area
3.00-4.30pm   Chihae Yang (MN-AM): Chemoinformatics approaches for chemical safety assessment: Genotoxic impurities of EFSA pesticides
3.30-4.00pm   oral communications

Poster Presentations

Processo automatico per identificare le impurezze del farmaco potenzialmente mutagene tramite metodi computazionali come descritto nelle esistenti linea guida dell'agenzia europea del farmaco" ("Automatic process to identify potentially mutagenic drug impurities using computational methods as described in the existing guidelines of the European Medicines Agency")
  Presented by Elena Fioravanzo
  Session on alimenti, biotrasformazione xenobiotici, botanicals, integratori alimentari, farmaci
  Tuesday, February 11, 2020, 1-2pm
ChemTunes·ToxGPS®, an In Silico Platform Facilitating Robust and Reproducible Read-Across Studies Utilizing Chemoinformatics and Safety Assessment Methods
  Presented by Elena Fioravanzo
  Session on cosmetici, pestcidi, tossicologia clinica e analitica, tossine naturali
  Wednesday, February 12, 2020, 1-2pm

Further information is available at the Congress pages and will be posted on this page as soon as available. We are looking forward to meeting you in Bologna.